Endocrine Abstracts

Background: Adipocyte and osteoblast derive from the same mesenchimal progenitor. Age-related decrease in bone mass is accompanied by an increase in marrow adipose tissue. Vitamin D3 (VD) inhibits adipogenesis in 3T3-L1 preadipocytes. Recently it has been demonstrated that alendronate (ALN) inhibits adipogenesis while promoting osteoblast differentiation of mesenchimal stem cells.Aim of the study: To evaluate the in vitro role of ALN on 3T3-L1 adi...

Drospirenone (DRSP) is a potent antimineralocorticoid with progestative and moderate antiandrogenic properties. We have previously shown that DRSP exerts a potent antiadipogenic activity in murine and human preadipocytes through specific antagonism of the MR. In the present study responses to DRSP were investigated in a model of diet-induced obesity for 12 weeks. Female 10-week-old C57bl6 mice were fed with normal chow or a high fat diet (HF, containing 45% fat by calories). M...